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single-particle interferometric resonance imaging sensor (sp-iris) with exoview  (Unchained Labs)
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Unchained Labs single-particle interferometric resonance imaging sensor (sp-iris) with exoview
(A) Ultrasensitive detection of neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) by single-molecule array (SIMOA) in plasma samples. (B) EVs were analyzed using the single-particle interferometric resonance imaging sensor (SP-IRIS, <t>ExoView,</t> Unchained Labs) after immunocapture with CD9, CD81, and CD63 antibodies directly in plasma. (C) EV isolation with size-exclusion chromatography (SmartSEC, System Biosciences) followed by the characterization of isolated EVs by Western blotting (WB), nanoparticle-tracking analysis (NTA), and cryo-electron microscopy (cryo-EM). Extended EV-specific marker analysis by bead-based flow cytometry (MACSPlex EV kit, Miltenyi) after size-exclusion chromatography-based EV isolation. The levels of 37 EV surface markers plus 2 isotype controls (MIgG, human IgG1 isotype control antibody [REA293]) were simultaneously monitored. Each type of EV capture bead was labeled with 1 of the 39 antibodies. Bound EVs were detected with a cocktail of APC-labeled CD9, CD81, and CD63 antibodies. Illustrations created in BioRender Falk, V. (2025) BioRender.com/uqfyfpg and Adobe Photoshop (v. 2024). EV = extracellular vesicle.
Single Particle Interferometric Resonance Imaging Sensor (Sp Iris) With Exoview, supplied by Unchained Labs, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sp-iris/pmc12056760-74-7-8?v=Unchained+Labs
Average 90 stars, based on 1 article reviews
single-particle interferometric resonance imaging sensor (sp-iris) with exoview - by Bioz Stars, 2026-07
90/100 stars
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single-particle interferometric resonance imaging sensor sp-iris  (Unchained Labs)
90
Unchained Labs single-particle interferometric resonance imaging sensor sp-iris
(A) Ultrasensitive detection of neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) by single-molecule array (SIMOA) in plasma samples. (B) EVs were analyzed using the single-particle interferometric resonance imaging sensor (SP-IRIS, <t>ExoView,</t> Unchained Labs) after immunocapture with CD9, CD81, and CD63 antibodies directly in plasma. (C) EV isolation with size-exclusion chromatography (SmartSEC, System Biosciences) followed by the characterization of isolated EVs by Western blotting (WB), nanoparticle-tracking analysis (NTA), and cryo-electron microscopy (cryo-EM). Extended EV-specific marker analysis by bead-based flow cytometry (MACSPlex EV kit, Miltenyi) after size-exclusion chromatography-based EV isolation. The levels of 37 EV surface markers plus 2 isotype controls (MIgG, human IgG1 isotype control antibody [REA293]) were simultaneously monitored. Each type of EV capture bead was labeled with 1 of the 39 antibodies. Bound EVs were detected with a cocktail of APC-labeled CD9, CD81, and CD63 antibodies. Illustrations created in BioRender Falk, V. (2025) BioRender.com/uqfyfpg and Adobe Photoshop (v. 2024). EV = extracellular vesicle.
Single Particle Interferometric Resonance Imaging Sensor Sp Iris, supplied by Unchained Labs, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sp-iris/10__1212_slash_nxi__0000000000200404-64-14-26?v=Unchained+Labs
Average 90 stars, based on 1 article reviews
single-particle interferometric resonance imaging sensor sp-iris - by Bioz Stars, 2026-07
90/100 stars
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single-particle interferometric reflectance imaging sensor-based (sp-iris) analyzer  (NanoView Biosciences)
90
NanoView Biosciences single-particle interferometric reflectance imaging sensor-based (sp-iris) analyzer
(A) Ultrasensitive detection of neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) by single-molecule array (SIMOA) in plasma samples. (B) EVs were analyzed using the single-particle interferometric resonance imaging sensor (SP-IRIS, <t>ExoView,</t> Unchained Labs) after immunocapture with CD9, CD81, and CD63 antibodies directly in plasma. (C) EV isolation with size-exclusion chromatography (SmartSEC, System Biosciences) followed by the characterization of isolated EVs by Western blotting (WB), nanoparticle-tracking analysis (NTA), and cryo-electron microscopy (cryo-EM). Extended EV-specific marker analysis by bead-based flow cytometry (MACSPlex EV kit, Miltenyi) after size-exclusion chromatography-based EV isolation. The levels of 37 EV surface markers plus 2 isotype controls (MIgG, human IgG1 isotype control antibody [REA293]) were simultaneously monitored. Each type of EV capture bead was labeled with 1 of the 39 antibodies. Bound EVs were detected with a cocktail of APC-labeled CD9, CD81, and CD63 antibodies. Illustrations created in BioRender Falk, V. (2025) BioRender.com/uqfyfpg and Adobe Photoshop (v. 2024). EV = extracellular vesicle.
Single Particle Interferometric Reflectance Imaging Sensor Based (Sp Iris) Analyzer, supplied by NanoView Biosciences, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sp-iris/pmc12170940-75-9-12?v=NanoView+Biosciences
Average 90 stars, based on 1 article reviews
single-particle interferometric reflectance imaging sensor-based (sp-iris) analyzer - by Bioz Stars, 2026-07
90/100 stars
  Buy from Supplier
single particle sp-iris  (NanoView Biosciences)
90
NanoView Biosciences single particle sp-iris
(A) Ultrasensitive detection of neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) by single-molecule array (SIMOA) in plasma samples. (B) EVs were analyzed using the single-particle interferometric resonance imaging sensor (SP-IRIS, <t>ExoView,</t> Unchained Labs) after immunocapture with CD9, CD81, and CD63 antibodies directly in plasma. (C) EV isolation with size-exclusion chromatography (SmartSEC, System Biosciences) followed by the characterization of isolated EVs by Western blotting (WB), nanoparticle-tracking analysis (NTA), and cryo-electron microscopy (cryo-EM). Extended EV-specific marker analysis by bead-based flow cytometry (MACSPlex EV kit, Miltenyi) after size-exclusion chromatography-based EV isolation. The levels of 37 EV surface markers plus 2 isotype controls (MIgG, human IgG1 isotype control antibody [REA293]) were simultaneously monitored. Each type of EV capture bead was labeled with 1 of the 39 antibodies. Bound EVs were detected with a cocktail of APC-labeled CD9, CD81, and CD63 antibodies. Illustrations created in BioRender Falk, V. (2025) BioRender.com/uqfyfpg and Adobe Photoshop (v. 2024). EV = extracellular vesicle.
Single Particle Sp Iris, supplied by NanoView Biosciences, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sp-iris/pm40465474-79-9-23?v=NanoView+Biosciences
Average 90 stars, based on 1 article reviews
single particle sp-iris - by Bioz Stars, 2026-07
90/100 stars
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single particle interferometric reflectance imaging sensing (sp-iris) using the exoview human tetraspanin kit  (NanoView Biosciences)
90
NanoView Biosciences single particle interferometric reflectance imaging sensing (sp-iris) using the exoview human tetraspanin kit
(A) Ultrasensitive detection of neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) by single-molecule array (SIMOA) in plasma samples. (B) EVs were analyzed using the single-particle interferometric resonance imaging sensor (SP-IRIS, <t>ExoView,</t> Unchained Labs) after immunocapture with CD9, CD81, and CD63 antibodies directly in plasma. (C) EV isolation with size-exclusion chromatography (SmartSEC, System Biosciences) followed by the characterization of isolated EVs by Western blotting (WB), nanoparticle-tracking analysis (NTA), and cryo-electron microscopy (cryo-EM). Extended EV-specific marker analysis by bead-based flow cytometry (MACSPlex EV kit, Miltenyi) after size-exclusion chromatography-based EV isolation. The levels of 37 EV surface markers plus 2 isotype controls (MIgG, human IgG1 isotype control antibody [REA293]) were simultaneously monitored. Each type of EV capture bead was labeled with 1 of the 39 antibodies. Bound EVs were detected with a cocktail of APC-labeled CD9, CD81, and CD63 antibodies. Illustrations created in BioRender Falk, V. (2025) BioRender.com/uqfyfpg and Adobe Photoshop (v. 2024). EV = extracellular vesicle.
Single Particle Interferometric Reflectance Imaging Sensing (Sp Iris) Using The Exoview Human Tetraspanin Kit, supplied by NanoView Biosciences, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sp-iris/pmc12149191-169-11-18?v=NanoView+Biosciences
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single particle interferometric reflectance imaging sensing (sp-iris) using the exoview human tetraspanin kit - by Bioz Stars, 2026-07
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single-particle interferometric reflectance imaging sensing (sp-iris) exoview r100 system  (NanoView Biosciences)
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NanoView Biosciences single-particle interferometric reflectance imaging sensing (sp-iris) exoview r100 system
(A) Ultrasensitive detection of neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) by single-molecule array (SIMOA) in plasma samples. (B) EVs were analyzed using the single-particle interferometric resonance imaging sensor (SP-IRIS, <t>ExoView,</t> Unchained Labs) after immunocapture with CD9, CD81, and CD63 antibodies directly in plasma. (C) EV isolation with size-exclusion chromatography (SmartSEC, System Biosciences) followed by the characterization of isolated EVs by Western blotting (WB), nanoparticle-tracking analysis (NTA), and cryo-electron microscopy (cryo-EM). Extended EV-specific marker analysis by bead-based flow cytometry (MACSPlex EV kit, Miltenyi) after size-exclusion chromatography-based EV isolation. The levels of 37 EV surface markers plus 2 isotype controls (MIgG, human IgG1 isotype control antibody [REA293]) were simultaneously monitored. Each type of EV capture bead was labeled with 1 of the 39 antibodies. Bound EVs were detected with a cocktail of APC-labeled CD9, CD81, and CD63 antibodies. Illustrations created in BioRender Falk, V. (2025) BioRender.com/uqfyfpg and Adobe Photoshop (v. 2024). EV = extracellular vesicle.
Single Particle Interferometric Reflectance Imaging Sensing (Sp Iris) Exoview R100 System, supplied by NanoView Biosciences, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sp-iris/pm40136938-156-16-29?v=NanoView+Biosciences
Average 90 stars, based on 1 article reviews
single-particle interferometric reflectance imaging sensing (sp-iris) exoview r100 system - by Bioz Stars, 2026-07
90/100 stars
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sp-iris exoview r200 platform  (Unchained Labs)
90
Unchained Labs sp-iris exoview r200 platform
(A) Ultrasensitive detection of neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) by single-molecule array (SIMOA) in plasma samples. (B) EVs were analyzed using the single-particle interferometric resonance imaging sensor (SP-IRIS, <t>ExoView,</t> Unchained Labs) after immunocapture with CD9, CD81, and CD63 antibodies directly in plasma. (C) EV isolation with size-exclusion chromatography (SmartSEC, System Biosciences) followed by the characterization of isolated EVs by Western blotting (WB), nanoparticle-tracking analysis (NTA), and cryo-electron microscopy (cryo-EM). Extended EV-specific marker analysis by bead-based flow cytometry (MACSPlex EV kit, Miltenyi) after size-exclusion chromatography-based EV isolation. The levels of 37 EV surface markers plus 2 isotype controls (MIgG, human IgG1 isotype control antibody [REA293]) were simultaneously monitored. Each type of EV capture bead was labeled with 1 of the 39 antibodies. Bound EVs were detected with a cocktail of APC-labeled CD9, CD81, and CD63 antibodies. Illustrations created in BioRender Falk, V. (2025) BioRender.com/uqfyfpg and Adobe Photoshop (v. 2024). EV = extracellular vesicle.
Sp Iris Exoview R200 Platform, supplied by Unchained Labs, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sp-iris/pm39979938-92-7-13?v=Unchained+Labs
Average 90 stars, based on 1 article reviews
sp-iris exoview r200 platform - by Bioz Stars, 2026-07
90/100 stars
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(A) Ultrasensitive detection of neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) by single-molecule array (SIMOA) in plasma samples. (B) EVs were analyzed using the single-particle interferometric resonance imaging sensor (SP-IRIS, ExoView, Unchained Labs) after immunocapture with CD9, CD81, and CD63 antibodies directly in plasma. (C) EV isolation with size-exclusion chromatography (SmartSEC, System Biosciences) followed by the characterization of isolated EVs by Western blotting (WB), nanoparticle-tracking analysis (NTA), and cryo-electron microscopy (cryo-EM). Extended EV-specific marker analysis by bead-based flow cytometry (MACSPlex EV kit, Miltenyi) after size-exclusion chromatography-based EV isolation. The levels of 37 EV surface markers plus 2 isotype controls (MIgG, human IgG1 isotype control antibody [REA293]) were simultaneously monitored. Each type of EV capture bead was labeled with 1 of the 39 antibodies. Bound EVs were detected with a cocktail of APC-labeled CD9, CD81, and CD63 antibodies. Illustrations created in BioRender Falk, V. (2025) BioRender.com/uqfyfpg and Adobe Photoshop (v. 2024). EV = extracellular vesicle.

Journal: Neurology® Neuroimmunology & Neuroinflammation

Article Title: Extracellular Vesicle Marker Changes Associated With Disease Activity in Relapsing-Remitting Multiple Sclerosis

doi: 10.1212/NXI.0000000000200404

Figure Lengend Snippet: (A) Ultrasensitive detection of neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) by single-molecule array (SIMOA) in plasma samples. (B) EVs were analyzed using the single-particle interferometric resonance imaging sensor (SP-IRIS, ExoView, Unchained Labs) after immunocapture with CD9, CD81, and CD63 antibodies directly in plasma. (C) EV isolation with size-exclusion chromatography (SmartSEC, System Biosciences) followed by the characterization of isolated EVs by Western blotting (WB), nanoparticle-tracking analysis (NTA), and cryo-electron microscopy (cryo-EM). Extended EV-specific marker analysis by bead-based flow cytometry (MACSPlex EV kit, Miltenyi) after size-exclusion chromatography-based EV isolation. The levels of 37 EV surface markers plus 2 isotype controls (MIgG, human IgG1 isotype control antibody [REA293]) were simultaneously monitored. Each type of EV capture bead was labeled with 1 of the 39 antibodies. Bound EVs were detected with a cocktail of APC-labeled CD9, CD81, and CD63 antibodies. Illustrations created in BioRender Falk, V. (2025) BioRender.com/uqfyfpg and Adobe Photoshop (v. 2024). EV = extracellular vesicle.

Article Snippet: Single-particle interferometric resonance imaging sensor (SP-IRIS) with ExoView (Unchained Labs, Pleasanton, CA) enables size and density measurement of EVs exhibiting membrane-bound tetraspanins CD9, CD63, and CD81 in crude plasma, without previous EV isolation.

Techniques: Clinical Proteomics, Single Particle, Imaging, Isolation, Size-exclusion Chromatography, Western Blot, Cryo-Electron Microscopy, Cryo-EM Sample Prep, Marker, Flow Cytometry, Control, Labeling